Staryl of sex
In the past several years we have studied the dietary influences on the genetic expression of the mouse stearoyl-Co A desaturase.The expression of the mouse SCD genes is regulated by polyunsaturated fatty acids and cholesterol at the levels of transcription and m RNA stability.The reason for having two SCD isoforms is not known but could be related to the substrate specificities of the two isomers and their regulation through tissue-specific expression.
Organization of the mouse SCD1 and SCD2 promoters and the nucleotide sequence similarity of the 110-bp segment in the 5′-flanking region of the mouse SCD2 and SCD1 genes.
SRE, sterol regulatory element; NF-Y, CCAAT-binding factor or nuclear factor Y binding site; C/EBP, CCAAT enhancer binding protein sequence.
Oleic acid and palmitoleic acid are the major monounsaturated fatty acids in fat depots and membrane phospholipids.
Overall, Δ9 desaturase affects the fatty acid composition of phospholipids and triglycerides.
Effects on phospholipid composition are important in the maintenance of membrane fluidity and alterations have been implicated in a variety of disease states (6).
These chemicals include additives or ingredients in pesticides, common household products, food, drugs, dyes, or solvents.